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Nat Cell Biol. 2019 Feb;21(2):122-132. doi: 10.1038/s41556-018-0223-z. Epub 2019 Jan 2.

Integrin trafficking in cells and tissues.

Author information

1
Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland.
2
Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland. johanna.ivaska@utu.fi.
3
Department of Biochemistry, University of Turku, Turku, Finland. johanna.ivaska@utu.fi.

Abstract

Cell adhesion to the extracellular matrix is fundamental to metazoan multicellularity and is accomplished primarily through the integrin family of cell-surface receptors. Integrins are internalized and enter the endocytic-exocytic pathway before being recycled back to the plasma membrane. The trafficking of this extensive protein family is regulated in multiple context-dependent ways to modulate integrin function in the cell. Here, we discuss recent advances in understanding the mechanisms and cellular roles of integrin endocytic trafficking.

PMID:
30602723
DOI:
10.1038/s41556-018-0223-z

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