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Cell. 1988 Dec 23;55(6):1159-69.

HIV expression strategies: ribosomal frameshifting is directed by a short sequence in both mammalian and yeast systems.

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Department of Biochemistry, University of Oxford, England.


The pol gene of the human immunodeficiency virus (HIV-1) is expressed as a gag:pol fusion, arising from a ribosomal frameshift that brings the overlapping, out-of-phase gag and pol genes into translational phase. In this study, we show that HIV frameshifting is mediated by a very short sequence in the viral RNA. We demonstrate the importance of a homopolymeric run within this sequence and conclude that HIV frameshifting is not dependent on stem-loop structures downstream from the frameshift site. Our analysis also indicates that the sequence requirements are identical in mammalian and yeast systems.

[Indexed for MEDLINE]

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