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Clin J Am Soc Nephrol. 2019 Jan 2. pii: CJN.08020718. doi: 10.2215/CJN.08020718. [Epub ahead of print]

MicroRNAs in Acute Kidney Injury and Kidney Transplantation.

Author information

1
Laboratory of Experimental Medicine and Pediatrics, University of Antwerp, Wilrijk, Belgium.
2
Department of Nephrology, Antwerp University Hospital, Edegem, Belgium.
3
Division of Renal Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden; and.
4
Section of Epigenetics, Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.
5
Laboratory of Experimental Medicine and Pediatrics, University of Antwerp, Wilrijk, Belgium; amaryllis.vancraenenbroeck@uantwerpen.be.

Abstract

MicroRNAs are epigenetic regulators of gene expression at the posttranscriptional level. They are involved in intercellular communication and crosstalk between different organs. As key regulators of homeostasis, their dysregulation underlies several morbidities including kidney disease. Moreover, their remarkable stability in plasma and urine makes them attractive biomarkers. Beyond biomarker studies, clinical microRNA research in nephrology in recent decades has focused on the discovery of specific microRNA signatures and the identification of novel targets for therapy and/or disease prevention. However, much of this research has produced equivocal results and there is a need for standardization and confirmation in prospective trials. This review aims to provide an overview of general concepts and available clinical evidence in both the pathophysiology and biomarker fields for the role of microRNA in AKI and kidney transplantation.

KEYWORDS:

Acute Kidney Injury; Biomarkers; Body Fluids; Homeostasis; MicroRNAs; Prospective Studies; kidney transplantation

PMID:
30602462
DOI:
10.2215/CJN.08020718

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