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Bioinformatics. 2019 Aug 15;35(16):2882-2884. doi: 10.1093/bioinformatics/bty1067.

UbiHub: a data hub for the explorers of ubiquitination pathways.

Author information

1
Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.
2
Structural Genomics Consortium, University of Oxford, Headington Oxford, Oxfordshire, UK.
3
Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.
4
Department of Chemistry and Biochemistry, University of Windsor, Windsor, ON, Canada.
5
Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Roosevelt Drive, Headington, Oxford, Oxfordshire, UK.

Abstract

MOTIVATION:

Protein ubiquitination plays a central role in important cellular machineries such as protein degradation or chromatin-mediated signaling. With the recent discovery of the first potent ubiquitin-specific protease inhibitors, and the maturation of proteolysis targeting chimeras as promising chemical tools to exploit the ubiquitin-proteasome system, protein target classes associated with ubiquitination pathways are becoming the focus of intense drug-discovery efforts.

RESULTS:

We have developed UbiHub, an online resource that can be used to visualize a diverse array of biological, structural and chemical data on phylogenetic trees of human protein families involved in ubiquitination signaling, including E3 ligases and deubiquitinases. This interface can inform target prioritization and drug design, and serves as a navigation tool for medicinal chemists, structural and cell biologists exploring ubiquitination pathways.

AVAILABILITY AND IMPLEMENTATION:

https://ubihub.thesgc.org.

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