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J Neurophysiol. 2019 Jan 2. doi: 10.1152/jn.00619.2018. [Epub ahead of print]

Functionally distinct language and Theory of Mind networks are synchronized at rest and during language comprehension.

Author information

1
Brain and Cognitive Sciences, MIT, United States.
2
Brain and Cognitive Sciences, Massachusetts institute of Technology, United States.
3
MGH, United States.

Abstract

Communication requires the abilities to generate and interpret utterances and to infer the beliefs, desires, and goals of others ("Theory of Mind", ToM). These two abilities have been shown to dissociate: individuals with aphasia retain the ability to think about others' mental states; and individuals with autism are impaired in social reasoning, but their basic language processing is often intact. In line with this evidence from brain disorders, fMRI studies have shown that linguistic and ToM abilities recruit distinct sets of brain regions. And yet, language is a social tool that allows us to share thoughts with one another. Thus, the language and ToM brain networks must share information in spite of being implemented in distinct neural circuits. Here, we investigated potential interactions between these networks during naturalistic cognition using functional correlations in fMRI. The networks were functionally defined in individual participants, in terms of preference for sentences over nonwords for language, and for belief inference over physical-event processing for ToM, with both a verbal and a nonverbal paradigm. Although, across experiments, inter-region correlations within each network were higher than between-network correlations, we also observed above-baseline synchronization of BOLD signal fluctuations between the two networks during rest and story comprehension. This synchronization was functionally specific: neither network was synchronized with the executive control network (functionally defined in terms of preference for a harder over easier version of an executive task). Thus, coordination between the language and ToM networks appears to be an inherent and specific characteristic of their functional architecture.

KEYWORDS:

communication; fMRI; functional connectivity; language; theory of mind

PMID:
30601693
DOI:
10.1152/jn.00619.2018

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