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Carbohydr Polym. 2019 Mar 1;207:371-381. doi: 10.1016/j.carbpol.2018.11.087. Epub 2018 Nov 27.

Inhibition of dextran sodium sulfate-induced colitis in mice by baker's yeast polysaccharides.

Author information

1
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China.
2
State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, 330047, China.
3
State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, 330047, China. Electronic address: spnie@ncu.edu.cn.
4
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China. Electronic address: xuxj@whu.edu.cn.

Abstract

Most of the reported yeast polysaccharides are a mixture of chitin, β-glucan and mannoprotein, leading to different biological activities. Herein, we report the structures and the anti-inflammation of the purified baker's yeast polysaccharides (BBG1-BBG4). Experimental data indicated that BBG1 was a highly branched β-(1,6)-glucan linked to mannoprotein; BBG2 was a linear β-(1,3)-glucan; BBG3 and BBG4 were mixtures of a β-(1,6)-branched β-(1,3)-glucan and a linear β-(1,3)-glucan. Of these, BBG1 exhibited stronger inhibition of pro-inflammatory mediators of NO/iNOS, IL-6, IL-1β, etc. at protein and/or mRNA levels in LPS-stimulated RAW264.7 cells through inhibiting MAPK signalling pathways. Orally administered BBG1 and BBG2 significantly decreased the pro-inflammatory mediators of IL-6, iNOS and IL-1β at protein and/or mRNA levels, as well as colonic mucosal damage and macrophages infiltration in DSS-induced colitis mice. All these findings suggest that yeast polysaccharides have potentials as anti-inflammatory drugs or adjuvants in the intestinal inflammation therapy.

KEYWORDS:

Anti-inflammation; Inflammatory bowel disease; Structure; Yeast glucan

PMID:
30600019
DOI:
10.1016/j.carbpol.2018.11.087
[Indexed for MEDLINE]

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