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Gynecol Endocrinol. 2019 Jan 1:1-4. doi: 10.1080/09513590.2018.1548593. [Epub ahead of print]

Lower vitamin D levels during the second trimester are associated with developing gestational diabetes mellitus: an observational cross-sectional study.

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a Department of Nutrition and Dietetics , Faculty of Health Sciences, Hacettepe University , Altındağ/Sıhhiye/Ankara , Turkey.
b Department of Obstetrics and Gynecology , University of Health Sciences , Ankara , Turkey.
c Department of Obstetrics and Gynecology , University of Kyrenia , Kyrenia , Cyprus.


In this study, we aimed to compare serum 25(OH)D levels in women with and without gestational diabetes mellitus (GDM), and to identify the serum 25(OH)D levels associated with GDM. We recruited 40 women with GDM and 40 healthy pregnant women, aged 20-40 years and in the second trimester, at Gulhane Education and Research Hospital. We excluded women with chronic diseases, preeclampsia, pre-GDM, multiple pregnancies, and those taking medications related to calcium or vitamin D metabolism. We took anthropometric measurements and blood samples during the second trimester. Of the 80 pregnant women, pre-pregnancy body mass index was significantly higher among the GDM group than the healthy group (26.4 ± 5.73 kg/m2 vs. 22.6 ± 3.56 kg/m2, p = .001). Serum 25(OH)D levels in women with GDM were significantly lower than those in healthy women (16.8 ± 9.90 ng/mL vs. 20.9 ± 8.16 ng/mL, p = .016). The prevalence of severe vitamin D deficiency was as high as 72.5% among women in the GDM group, with a 1.74-fold increased risk of deficient status. Levels of 25(OH)D lower than a cutoff value of 14.0 ng/mL were determined to be related to GDM. These study results suggest that maternal vitamin D deficiency in mid-pregnancy is significantly associated with development of GDM.


25(OH)D; Gestational diabetes mellitus; pregnancy; second trimester; vitamin D deficiency

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