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Biomater Res. 2018 Dec 20;22:37. doi: 10.1186/s40824-018-0147-5. eCollection 2018.

Silicone breast implant modification review: overcoming capsular contracture.

Shin BH1, Kim BH1, Kim S2, Lee K2,3, Choy YB1,4,5, Heo CY4,6,7.

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1Department of Biomedical Engineering, Seoul National University College of Medicine, Seoul, 03080 Republic of Korea.
2Department of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, 08826 Republic of Korea.
7Advanced Institutes of Convergence Technology, Suwon, Gyeonggi-do 16229 South Korea.
3Interdisciplinary Program for Bioengineering, College of Engineering, Seoul National University, Seoul, 08826 Republic of Korea.
6Institute of Medical & Biological Engineering, Medical Research Center, Seoul National University, Seoul, 03080 Republic of Korea.
4Department of Plastic and Reconstructive Surgery, College of Medicine, Seoul National University, Seoul, 03080 Republic of Korea.
5Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam, 13620 Republic of Korea.



Silicone implants are biomaterials that are frequently used in the medical industry due to their physiological inertness and low toxicity. However, capsular contracture remains a concern in long-term transplantation. To date, several studies have been conducted to overcome this problem. This review summarizes and explores these trends.

Main body:

First, we examined the overall foreign body response from initial inflammation to fibrosis capsule formation in detail and introduced various studies to overcome capsular contracture. Secondly, we introduced that the main research approaches are to inhibit fibrosis with anti-inflammatory drugs or antibiotics, to control the topography of the surface of silicone implants, and to administer plasma treatment. Each study examined aspects of the various mechanisms by which capsular contracture could occur, and addressed the effects of inhibiting fibrosis.


This review introduces various silicone surface modification methods to date and examines their limitations. This review will help identify new directions in inhibiting the fibrosis of silicone implants.


Capsular contracture; Fibrosis; Foreign body reaction; Inflammation; Modification; Silicone implant

Conflict of interest statement

Not applicableNot applicableThe authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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