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Nutrients. 2018 Dec 28;11(1). pii: E60. doi: 10.3390/nu11010060.

Protection of UVB-Induced Photoaging by Fuzhuan-Brick Tea Aqueous Extract via MAPKs/Nrf2-Mediated Down-Regulation of MMP-1.

Author information

1
Department of Food Science and Biotechnology, Graduate School, Kyungpook National University, Daegu 41566, Korea. laputaily@hotmail.com.
2
Department of Food Science and Biotechnology, Graduate School, Kyungpook National University, Daegu 41566, Korea. mbalam@knu.ac.kr.
3
Food and Bio-Industry Research Institute, Inner Beauty/Antiaging Center, Kyungpook National University, Daegu 41566, Korea. mbalam@knu.ac.kr.
4
Department of Food Science and Biotechnology, Graduate School, Kyungpook National University, Daegu 41566, Korea. sang@knu.ac.kr.
5
Food and Bio-Industry Research Institute, Inner Beauty/Antiaging Center, Kyungpook National University, Daegu 41566, Korea. sang@knu.ac.kr.

Abstract

Ultraviolet B (UVB) irradiation is viewed as the principal inducer of skin photo-aging, associated with acceleration of collagen degradation and upregulation of matrix metalloproteinases (MMPs). The ethnic groups of southern/western China use Fuzhuan brick-tea (FBT) as a beverage and as a nutritional supplement. In this study, we scrutinized the antagonistic effects of aqueous extract of Fuzhuan-brick tea (FBTA) on skin photo-aging in UVB-exposed human keratinocyte (HaCaT) cells. FBTA exhibited strong antioxidant activity and quenched UVB-induced generation of cellular reactive oxygen species (ROS) without showing any toxicity. FBTA was capable of combating oxidative stress by augmenting messenger RNA (mRNA) and protein levels of both phase I and phase II detoxifying enzymes, especially heme oxygenase 1 (HO-1), by upregulating the nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated pathway in HaCaT cells via the phosphorylation of p38 and extracellular signal-regulated kinase (ERK). FBTA also downregulated the expression of matrix metalloproteinase-1 (MMP-1) while upregulating type I procollagen by modulating Nrf2 signaling in UVB-irradiated HaCaT cells. Collectively, our results show that FBTA might be useful as a functional food while being a good candidate in the development of cosmetic products and medicines for the remedy of UVB-induced skin photo-aging.

KEYWORDS:

anti-oxidant; anti-photoaging; heme oxygenase-1; matrix metalloproteinase-1 (MMP-1); nuclear factor erythroid 2-related factor 2 (Nrf2)

PMID:
30597920
PMCID:
PMC6357030
DOI:
10.3390/nu11010060
[Indexed for MEDLINE]
Free PMC Article

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