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J Biophotonics. 2019 Apr;12(4):e201800400. doi: 10.1002/jbio.201800400. Epub 2019 Jan 28.

Portable spectroscopic system for in vivo skin neoplasms diagnostics by Raman and autofluorescence analysis.

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Samara National Research University, Department of Laser and Biotechnical Systems, Samara, Russia.
Samara State Medical University, Department of Oncology, Samara, Russia.
Samara Regional Clinical Oncology Dispensary, Department of Visual Localization Tumors, Samara, Russia.


The present paper studies the applicability of a portable cost-effective spectroscopic system for the optical screening of skin tumors. in vivo studies of Raman scattering and autofluorescence (AF) of skin tumors with the 785 nm excitation laser in the near-infrared region included malignant melanoma, basal cell carcinoma and various types of benign neoplasms. The efficiency of the portable system was evaluated by comparison with a highly sensitive spectroscopic system and with the diagnosis accuracy of a human oncologist. Partial least square analysis of Raman and AF spectra was performed; specificity and sensitivity of various skin oncological pathologies detection varied from 78.9% to 100%. Hundred percent accuracy of benign and malignant skin tumors differentiation is possible only with a combined analysis of Raman and AF signals.


Raman spectroscopy; autofluorescence; malignancy; melanoma; optical biopsy; partial least square analysis; portable spectroscopic equipment; skin neoplasms


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