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Nutr Cancer. 2019;71(4):569-574. doi: 10.1080/01635581.2018.1540718. Epub 2018 Dec 29.

Clinical Significance of Prognostic Nutritional Index for Patients with Diffuse Large B-cell Lymphoma.

Yu W1,2, Guo Q3, Wang Z4, Mao L1,2, Wei J1, Jin J1,2, Wang J1,2.

Author information

1
a The Department of Hematology, the First Affiliated Hospital , College of Medicine, Zhejiang University , Hangzhou , China.
2
b Zhejiang Provincial Key Lab of Hematopoietic Malignancy , Zhejiang University , Hangzhou , China.
3
c The Department of Nephrology, the First Affiliated Hospital , College of Medicine, Zhejiang University , Hangzhou , China.
4
d The Department of Pathology, the First Affiliated Hospital , College of Medicine, Zhejiang University , Hangzhou , China.

Abstract

To analyze the clinical characteristics and prognostic value of prognostic nutritional index (PNI) for diffuse large B-cell lymphoma (DLBCL) treated in the rituximab era, baseline clinical and disease characteristics were recorded in our hospital. Concentration of T-helper cell type (Th1/Th2/Th17) cytokine profiles were measured by flow cytometry. DLBCL patients were classified into low and high PNI group based on the cutoff value as previously reported. Clinical features and survivals were compared between high and low group. In all, 114 (37%) out of 309 patients were classified as low PNI group. The low group had lower levels of albumin, hemoglobin and lymphocyte counts, and older age, and high lactate dehydroxygenase (LDH), and high frequencies of advanced stage, poor performance status, B symptoms, extranodal involvement, and higher level of interferon gamma (INF-γ). Low PNI was associated with poor overall survival (OS) in univariate analyses. But these significances did not stand in the paired patients matched by the well-established prognostic factors. In parallel, there was no significance between survival and PNI in the multivariate analyses. PNI was closely correlated with the well-established prognostic factors for DLBCL patients and was not an independent prognostic factor in our study.

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