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Epilepsy Behav Case Rep. 2018 Jul 17;10:141-144. doi: 10.1016/j.ebcr.2018.07.004. eCollection 2018.

Successful use of pure cannabidiol for the treatment of super-refractory status epilepticus.

Author information

1
Department of Pediatrics (Division of Neurology), David Geffen School of Medicine and UCLA Mattel Children's Hospital, Los Angeles, CA, USA.
2
Department of Neurology, David Geffen School of Medicine and UCLA Mattel Children's Hospital, Los Angeles, CA, USA.

Abstract

We present the case of a child with long-standing, super-refractory status epilepticus (SRSE) who manifested prompt and complete resolution of SRSE upon exposure to pure cannabidiol. SRSE emerged in the context of remote suspected encephalitis with previously well-controlled epilepsy. We discuss the extent to which response may be specifically attributed to cannabidiol, with consideration and discussion of multiple potential drug-drug interactions. Based on this case, we propose that adjunctive cannabidiol be considered in the treatment of SRSE.

KEYWORDS:

Cannabidiol; EEG; Pediatric; Status epilepticus

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