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Dev Cell. 2018 Dec 20. pii: S1534-5807(18)31030-X. doi: 10.1016/j.devcel.2018.11.046. [Epub ahead of print]

Chloroplast-to-Nucleus Signaling Regulates MicroRNA Biogenesis in Arabidopsis.

Author information

1
Center for Plant Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China; Tsinghua-Peking Center for Life Sciences, Beijing 100084, China.
2
Center for Plant Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.
3
Center for Plant Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China; Tsinghua-Peking Center for Life Sciences, Beijing 100084, China. Electronic address: qiyijun@tsinghua.edu.cn.

Abstract

As integral regulators in plant development and stress response, microRNAs (miRNAs) themselves need to be tightly regulated. Here, we show that tocopherols (vitamin E), lipid-soluble antioxidants synthesized from tyrosine in chloroplasts, positively regulate the biogenesis of miRNAs. Tocopherols are required for the accumulation of 3'-phosphoadenosine 5'-phosphate (PAP), a retrograde inhibitor of the nuclear exoribonucleases (XRN), which may protect primary miRNAs from being degraded and promote mature miRNA production. Such regulation is involved in heat-induced accumulation of miR398 and plant acquisition of heat tolerance. Our study reveals a chloroplast-to-nucleus signaling mechanism that favors miRNA biogenesis under heat and possibly other environmental perturbations.

KEYWORDS:

chloroplast; exoribonuclease; heat tolerance; miRNA; microRNA; plastid; retrograde signaling; stress response; tocopherol

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