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Bull Cancer. 2018 Dec;105 Suppl 1:S101-S112. doi: 10.1016/S0007-4551(18)30395-3.

Nouvelles stratégies innovantes en immunothérapie.

[Article in French]

Author information

1
Université de Bourgogne Franche-Comté, 21000 Dijon, France; Centre Georges-François-Leclerc, département d'oncologie médicale, 1, rue du Professeur-Marion, 21000 Dijon, France; Inserm LNC U1231, 21000 Dijon, France. Electronic address: Fghiringhelli@cgfl.fr.

Abstract

Recent advances in immuno-oncology with the development of anti-PD1/PD-L1 antibodies are revolutionizing oncological management. Immuno-oncology I currently developing in most histological types of cancer. However, the rate of success of anti-PD1/PD-L1 antibodies in monotherapy is limited by a limited to a subpopulation of patients accounting for about 25-30 % of patients in most indications. The development of new strategies is based on this observation with the aim to predict response or enhancing response rate. Thus, we note the development of different strategies aimed at better selecting patients or combining inhibitory checkpoints with other therapies in order to increase their effectiveness. This review will study therapeutic test strategies to validate these new associations.

KEYWORDS:

Biomarkers; Biomarqueurs; Checkpoint inhibitors; Chimio-immunothérapie; Immunotherapy; Immunothérapie

PMID:
30595191
DOI:
10.1016/S0007-4551(18)30395-3
[Indexed for MEDLINE]

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