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Int J Biol Macromol. 2019 Apr 1;126:475-477. doi: 10.1016/j.ijbiomac.2018.12.250. Epub 2018 Dec 27.

Modulation of cytokine level and sperm quality of mice by Lycium barbarum polysaccharides.

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College of medical technology, Shanghai University of Medicine & Health Sciences, 279 Zhouzhu Road, Shanghai 201318, China. Electronic address:


This study investigated the effect of Lycium barbarum polysaccharides (LBPs) on the cytokine level and sperm quality of mice with cyclophosphamide-induced impaired reproduction system. Sixty Kunming mice were randomly divided into five groups: a normal control group, a model control group (treated with cyclophosphamide) and three LBP groups (treated with cyclophosphamide and 0.5, 1.0 and 1.5 g/kg LBPs). LBP treatment improved the serum interleukin (IL)-2, IL-12 and tumour necrosis factor-α levels, as well as the sperm density and the movement and rate of normal morphology of sperm of mice with impaired reproduction system. However, a high level of LBP administration (1.5 g/kg) did not further increase the efficiency. Thus, LBPs demonstrated as potential immunomodulator to improve the cytokine level and sperm quality of mice.


Cytokine; Lycium barbarum; Polysaccharides

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