Format

Send to

Choose Destination
Neuropsychologia. 2019 Feb 18;124:9-18. doi: 10.1016/j.neuropsychologia.2018.12.020. Epub 2018 Dec 27.

Understanding perirhinal contributions to perception and memory: Evidence through the lens of selective perirhinal damage.

Author information

1
Department of Psychology, University of California, Davis, CA, USA.
2
Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH, USA.
3
Department of Psychology and Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA.
4
Department of Psychology, University of Toronto, Ontario, Canada.
5
Department of Psychology, University of Toronto Scarborough, Ontario, Canada.
6
Brain and Mind Institute and Department of Psychology, Western University, London, Ontario, Canada.
7
Department of Neurology, New York University School of Medicine, Langone Medical Center, New York, NY, USA; Department of Psychology, New York University, New York, NY, USA.
8
Department of Neurology, New York University School of Medicine, Langone Medical Center, New York, NY, USA; Department of Physiology, Neuroscience and Behavioral Sciences, St. George's University School of Medicine, St. George, Grenada.
9
Department of Neurology, New York University School of Medicine, Langone Medical Center, New York, NY, USA.
10
Department of Neurology, New York University School of Medicine, Langone Medical Center, New York, NY, USA; Department of Neurosurgery, New York University School of Medicine, New York, NY, USA; Department of Psychiatry, New York University School of Medicine, New York, NY, USA.
11
Department of Psychology, Columbia University, New York, NY, USA; Nathan Kline Institute, Orangeburg, NY, USA. Electronic address: ld24@columbia.edu.

Abstract

Although a memory systems view of the medial temporal lobe (MTL) has been widely influential in understanding how memory processes are implemented, a large body of work across humans and animals has converged on the idea that the MTL can support various other decisions, beyond those involving memory. Specifically, recent work suggests that perception of and memory for visual representations may interact in order to support ongoing cognition. However, given considerations involving lesion profiles in neuropsychological investigations and the correlational nature of fMRI, the precise nature of representations supported by the MTL are not well understood in humans. In the present investigation, three patients with highly specific lesions to MTL were administered a task that taxed perceptual and mnemonic judgments with highly similar face stimuli. A striking double dissociation was observed such that I.R., a patient with a cyst localized to right posterior PRc, displayed a significant impairment in perceptual discriminations, whereas patient A.N., an individual with a lesion in right posterior parahippocampal cortex and the tail of the right hippocampus, and S.D., an individual with bilateral hippocampal damage, did not display impaired performance on the perceptual task. A.N. and S.D. did, however, show impairments in memory performance, whereas patient I.R. did not. These results causally implicate right PRc in successful perceptual oddity judgments, however they suggest that representations supported by PRc are not necessary for correct mnemonic judgments, even in situations of high featural overlap.

KEYWORDS:

Hippocampus; Medial temporal lobe; Memory; Perception; Perirhinal cortex

PMID:
30594569
PMCID:
PMC6456260
[Available on 2020-02-18]
DOI:
10.1016/j.neuropsychologia.2018.12.020

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center