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Trends Endocrinol Metab. 2018 Dec 26. pii: S1043-2760(18)30214-5. doi: 10.1016/j.tem.2018.12.001. [Epub ahead of print]

Timing Matters: Circadian Effects on Energy Homeostasis and Alzheimer's Disease.

Author information

1
Centre for Neuroendocrinology and Brain Health Research Centre, Department of Physiology, School of Medical Sciences, University of Otago, Dunedin 9054, New Zealand; These authors contributed equally to this work.
2
Centre for Neuroendocrinology and Brain Health Research Centre, Department of Physiology, School of Medical Sciences, University of Otago, Dunedin 9054, New Zealand. Electronic address: alexander.tups@otago.ac.nz.

Abstract

Metabolic syndrome and Alzheimer's disease (AD) are two major health issues in modern society causing an extraordinary financial burden for the global healthcare systems. A tight link between the pathologies of obesity and type 2 diabetes (T2D), and more recently between T2D and AD, has been discovered. Furthermore, in recent years it has become apparent that the circadian clock has an important function in controlling metabolism. This review integrates the role of the circadian clock in the development of these metabolic derangements and vice versa. Common features such as central insulin resistance, altered glycogen synthase kinase 3β (GSK3β) signalling, and central inflammation are discussed, and therapeutic interventions targeting those mechanisms are mentioned briefly.

KEYWORDS:

diabetes; hypothalamus; inflammation; insulin; leptin; signal transduction

PMID:
30594436
DOI:
10.1016/j.tem.2018.12.001

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