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J Ultrasound Med. 2018 Dec 28. doi: 10.1002/jum.14915. [Epub ahead of print]

Diagnostic Performance of Multimodal Sound Touch Elastography for Differentiating Benign and Malignant Breast Masses.

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Department of Ultrasound, Second Clinical College of Jinan University, Shenzhen People's Hospital, Shenzhen, China.
The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, and The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, Jinan, China.



Evaluating the value of screening breast masses by separate or combined use of multimodal Sound Touch Elastography.


Women with 159 masses (mean size, 14.86 ± 6.57 mm; range, 5.30-30.00 mm) were enrolled in the study. The pathology results were adopted as diagnostic standards. The abilities of Young's modulus (E), shear modulus (G), and shear wave (C) to differentiate malignant and benign breast masses based on receiver operating characteristic curves were evaluated, and the optimal cutoff values were obtained. Sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio were calculated. Then, the values were combined to perform an overall analysis of Sound Touch Elastography using evidence-based medicine, construct forest plots, and calculate areas under the summary receiver operating characteristic curves, pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic scores.


A total of 159 masses with a mean size of 14.86 ± 6.57 mm (range, 5.30-30.00 mm) were included. For the various parameters, the diagnostic values were as follows: Gmax  > Emax  > Cmax  > Csd  > Esd  > Gsd  > Emean  > Gmean  > Cmean . There were no significant differences in Emin , Gmin , or Cmin . When the 9 parameters were combined, the pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic scores and areas under the summary receiver operating characteristic curves were 84% (95% confidence interval [CI], 79%-88%), 82% (95% CI, 80%-84%), 4.75 (95% CI, 4.15-5.43), 0.20 (95% CI, 0.15-0.25), 3.19 (95% CI, 2.84-3.54) and 90.2% (95% CI, 87%-92%), respectively.


Sound Touch Elastography can be recognized as a new ultrasound-based diagnostic method for differentiation between benign and malignant breast masses.


Sound Touch Elastography; breast cancer; diagnosis; elasticity imaging techniques; ultrasound


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