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Methods Mol Biol. 2019;1911:247-261. doi: 10.1007/978-1-4939-8976-8_17.

Investigating Hepatitis C Virus Infection Using Super-Resolution Microscopy.

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Quantitative Imaging and Nanobiophysics Group, MRC Laboratory for Molecular Cell Biology, Department of Cell and Developmental Biology, University College London, London, UK.
Division of Infection and Immunity, Institute of Immunity and Transplantation, University College London, London, UK.


Super-resolution microscopy (SRM) can provide a window on the nanoscale events of virus replication. Here we describe a protocol for imaging hepatitis C virus-infected cells using localization SRM. We provide details on sample preparation, immunostaining, data collection, and super-resolution image reconstruction. We have made all efforts to generalize the protocol to make it accessible to all budding super-resolution microscopists.


Hepatitis; Imaging; Microscopy; Super-resolution; Virus

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