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J Cell Mol Med. 2019 Mar;23(3):2064-2076. doi: 10.1111/jcmm.14114. Epub 2018 Dec 27.

Inhibition of stearoyl CoA desaturase-1 activity suppresses tumour progression and improves prognosis in human bladder cancer.

Author information

1
Department of Urology, The First Hospital of China Medical University, Shenyang, Liaoning, P.R. China.

Abstract

Urinary bladder neoplasm is one of the most common cancers worldwide. Cancer stem cells (CSCs) have been proven to be an important cause of cancer progression and poor prognosis. In the present study, we established bladder CSCs and identified the crucial differentially expressed genes (DEGs) between these cells and parental bladder cancer cells. Analyses of bioinformatics data and clinical samples from local hospitals showed that stearoyl CoA desaturase-1 (SCD) was the key factor among the DEGs. A significant correlation between SCD gene expression and poor prognosis among patients with bladder cancer was observed in our data. Loss-of-function experiments further revealed that the SCD inhibitor A939572 and SCD gene interference reduced cell proliferation and invasion. The above data suggest that SCD may serve as a novel marker for the prediction of tumour progression and poor prognosis in patients with bladder cancer.

KEYWORDS:

cancer stem cells; cell proliferation; stearoyl CoA desaturase-1; urinary bladder neoplasm

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