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IUBMB Life. 2018 Dec 27. doi: 10.1002/iub.1991. [Epub ahead of print]

Role of vitamin E in nonalcoholic fatty liver disease.

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Division of Health Science, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
Division of Metabolism and Biosystemic Science, Department of Medicine, Asahikawa Medical University, Asahikawa, Japan.


Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases worldwide. NAFLD manifests as hepatic lipid accumulation, insulin resistance, and inflammation, and can progress to nonalcoholic steatohepatitis (NASH) and cirrhosis. However, the underlying mechanisms of NAFLD, including those that drive its progression, are unclear. Both liver-resident (Kupffer cells) and recruited macrophages play a crucial role in the development of insulin resistance and NASH. Therefore, NALFD could potentially be ameliorated by modifying the polarization of macrophages/Kupffer cells. Reactive oxygen species induce oxidative stress, which is implicated in the progression of NASH. Micronutrients, including vitamins, are potent antioxidants that exert anti-inflammatory effects, and are used in the treatment of NAFLD. We review here the molecular mechanisms of the pathogenesis of NAFLD and the potential utility of vitamin E in its prevention and/or treatment.


Kupffer cells; nonalcoholic fatty liver disease; nonalcoholic steatohepatitis; oxidative stress; reactive oxygen species; vitamin E


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