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Brain Behav. 2019 Jan;9(1):e01205. doi: 10.1002/brb3.1205. Epub 2018 Dec 27.

Resting-state connectivity within and across neural circuits in anorexia nervosa.

Author information

1
Department of Psychiatry, Columbia University Irving Medical Center, New York, New York.
2
Department of Psychiatry, New York State Psychiatric Institute, New York, New York.
3
Rockefeller University, New York, New York.
4
Division of Mental Health Data Science, New York State Psychiatric Institute, New York, New York.
5
Department of Biostatistics, Columbia University Irving Medical Center, New York, New York.

Abstract

INTRODUCTION:

Obsessional thoughts and ritualized eating behaviors are characteristic of Anorexia Nervosa (AN), leading to the common suggestion that the illness shares neurobiology with obsessive-compulsive disorder (OCD). Resting-state functional connectivity MRI (rs-fcMRI) is a measure of functional neural architecture. This longitudinal study examined functional connectivity in AN within the limbic cortico-striato-thalamo-cortical (CSTC) loop, as well as in the salience network, the default mode network, and the executive control network (components of the triple network model of psychopathology).

METHODS:

Resting-state functional connectivity MRI scans were collected in unmedicated female inpatients with AN (n = 25) and healthy controls (HC; n = 24). Individuals with AN were scanned before and after weight restoration and followed for one month after hospital discharge. HC were scanned twice over the same timeframe.

RESULTS:

Using a seed-based correlation approach, individuals with AN had increased connectivity within the limbic CSTC loop when underweight, only. There was no significant association between limbic CSTC connectivity and obsessive-compulsive symptoms or prognosis. Exploratory analyses of functional network connectivity within the triple network model showed reduced connectivity between the salience network and left executive control network among AN relative to HC. These abnormalities persisted following weight restoration.

CONCLUSIONS:

The CSTC findings suggest that the neural underpinnings of obsessive-compulsive symptoms may differ from those of OCD. The inter-network abnormalities warrant examination in relation to illness-specific behaviors, namely abnormal eating behavior. This longitudinal study highlights the complexity of the neural underpinnings of AN.

KEYWORDS:

anorexia nervosa; connectivity; executive control network; orbitofrontal cortex; salience network; striatum; triple network model

PMID:
30590873
PMCID:
PMC6373651
DOI:
10.1002/brb3.1205
[Indexed for MEDLINE]
Free PMC Article

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