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J Ethnopharmacol. 1988 Sep;24(1):101-6.

Screening for antimalarial activity in the genus Potomorphe.

Author information

1
Fundação Oswaldo Cruz I.O.C., Departamento de Fisiologia e Farmacodinâmica, Rio de Janeiro, Brazil.

Abstract

Ethanolic extracts (CEE) of leaves from Potomorphe umbellata and Potomorphe peltata, popularly said to have antimalarial capacity, were submitted to the 4-day suppressive test in Plasmodium berghei-infected mice. The CEE of P. umbellata administered either orally (250 and 1250 mg/kg) or subcutaneously (100 and 500 mg/kg) evidenced strong antimalarial activity, significantly reducing the levels of parasitaemia in a dose-dependent manner. On the other hand, the CEE of P. peltata was ineffective in lowering the parasitemic levels in malarious mice, which had been treated either orally (500 mg/kg) or subcutaneously (20, 100 and 500 mg/kg). An ethanol extract of the dry whole plant of P. peltata was also inactive.

PMID:
3059067
DOI:
10.1016/0378-8741(88)90140-7
[Indexed for MEDLINE]

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