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J Infect Dis. 2018 Dec 25. doi: 10.1093/infdis/jiy741. [Epub ahead of print]

Haemophilus-dominant nasopharyngeal microbiota is associated with delayed clearance of respiratory syncytial virus in infants hospitalized for bronchiolitis.

Author information

1
Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA.
2
Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
3
Department of Molecular Virology and Microbiology, Houston, TX.
4
Pediatrics, Baylor College of Medicine, Houston, TX.
5
Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX.

Abstract

The relation of nasopharyngeal microbiota to the clearance of respiratory syncytial virus (RSV) in infants hospitalized for bronchiolitis is not known. In a multicenter cohort, we found 106 of 557 (19%) infants hospitalized with RSV bronchiolitis had the same RSV subtype 3 weeks later (i.e., delayed clearance of RSV). Using 16S rRNA gene sequencing and a clustering approach, infants with a Haemophilus-dominant microbiota profile at hospitalization were more likely than those with a mixed-profile to have delayed clearance after adjusting for 11 factors, including viral load. Nasopharyngeal microbiota composition is associated with delayed RSV clearance.

PMID:
30590603
DOI:
10.1093/infdis/jiy741

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