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Clin Infect Dis. 2018 Dec 24. doi: 10.1093/cid/ciy1112. [Epub ahead of print]

A Cluster of Cefepime-induced Neutropenia during Outpatient Parenteral Antimicrobial Therapy.

Author information

1
Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
2
Center for Clinical Excellence, BJC HealthCare, St. Louis, MO, USA.
3
Department of Pharmacy, Barnes-Jewish Hospital, St. Louis, MO, USA.
4
Department of Pharmacy Practice, St. Louis College of Pharmacy, St. Louis, MO, USA.
5
BJC Home Care Services, St. Louis, MO, USA.

Abstract

A cluster of cefepime-induced neutropenia (CIN) was identified from June 2017 to May 2018 in a regional outpatient parenteral antimicrobial therapy population. Our data suggest prolonged courses of cefepime (≥2 weeks) administered by rapid intravenous push were associated with a higher risk of CIN.

PMID:
30590400
DOI:
10.1093/cid/ciy1112

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