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Mov Disord. 2018 Dec 27. doi: 10.1002/mds.27587. [Epub ahead of print]

Cost-Effectiveness of Magnetic Resonance-Guided Focused Ultrasound for Essential Tremor.

Author information

1
Health Quality Ontario, Toronto, Ontario, Canada.
2
Morton and Gloria Shulman Movement Disorders Centre, Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada.
3
Division of Neurology, University of Toronto, Toronto, Ontario, Canada.
4
Krembil Research Institute, Toronto, Ontario, Canada.

Abstract

BACKGROUND:

Radiofrequency thalamotomy and deep brain stimulation are current treatments for moderate to severe medication-refractory essential tremor. However, they are invasive and thus carry risks. Magnetic resonance-guided focused ultrasound is a new, less invasive surgical option. The objective of the present study was to determine the cost-effectiveness of magnetic resonance-guided focused ultrasound compared with standard treatments in Canada.

METHODS:

We conducted a cost-utility analysis using a Markov cohort model. We compared magnetic resonance-guided focused ultrasound with no surgery in people ineligible for invasive neurosurgery and with radiofrequency thalamotomy and deep brain stimulation in people eligible for invasive neurosurgery. In the reference case analysis, we used a 5-year time horizon and a public payer perspective and discounted costs and benefits at 1.5% per year.

RESULTS:

Compared with no surgery in people ineligible for invasive neurosurgery, magnetic resonance-guided focused ultrasound cost $21,438 more but yielded 0.47 additional quality-adjusted life years, producing an incremental cost-effectiveness ratio of $45,817 per quality-adjusted life year gained. In people eligible for invasive neurosurgery, magnetic resonance-guided focused ultrasound was slightly less effective but much less expensive compared with the current standard of care, deep brain stimulation. The results were sensitive to assumptions regarding the time horizon, cost of magnetic resonance-guided focused ultrasound, and probability of recurrence.

CONCLUSIONS:

In people ineligible for invasive neurosurgery, the incremental cost-effectiveness ratio of magnetic resonance-guided focused ultrasound versus no surgery is comparable to many other tests and treatments that are widely adopted in high-income countries. In people eligible for invasive neurosurgery, magnetic resonance-guided focused ultrasound is also a reasonable option. © 2018 International Parkinson and Movement Disorder Society.

KEYWORDS:

cost-effectiveness; deep brain stimulation; essential tremor; focused ultrasound; radiofrequency thalamotomy

PMID:
30589951
DOI:
10.1002/mds.27587

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