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J Cancer Res Ther. 2018;14(7):1660-1664. doi: 10.4103/jcrt.JCRT_1032_17.

125I seeds implantation for an elderly patient of skin squamous cell carcinomas with ulcer guided by ultrasound.

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Graduate School of Hebei Medical University, Shijiazhuang, Hebei Province, China.
Department of Oncology, The Hebei General Hospital, Shijiazhuang, Hebei Province, China.


The skin squamous cell carcinoma (SCC) is a kind of malignancy of keratinocytes. SCC was originated within the epidermis or relevant appendages, which commonly occurred on sunlight exposure sites, such as the head and neck. This case report described an 85-year-old female patient with skin SCC at the right frontal, accompanied with skin ulcer. This patient suffered from indications that were not suitable for surgical resection, including old age, Alzheimer's disease (AD), lacunar infarction, hydropericardium, and some other concomitant diseases. In addition, the external beam radiotherapy was rejected by the relatives of this patient. Then, the patient received 125I seeds interstitial brachytherapy guided by bedside ultrasound. The tumor response was evaluated based on the response evaluation criteria in solid tumors version 1.1 criteria. Complete response was achieved 4 months after brachytherapy. No complications and recurrence were observed during 8-month follow-up. As the sole modality, the 125I seeds implantation could be a reasonable and safe alternative for treating skin SCC with ulcer, especially for the elderly patients.


125I seeds; aged; basal cell carcinoma; brachytherapy; nonmelanoma skin cancer

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