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J Cancer Res Ther. 2018;14(7):1638-1643. doi: 10.4103/0973-1482.187352.

Probing pathway-related modules in invasive squamous cervical cancer based on topological centrality of network strategy.

Author information

Department of Obstetrics, Binzhou People's Hospital, Binzhou 256610, China.
Department of Gynecology, Binzhou People's Hospital, Binzhou 256610, China.
Department of Gynecology and Obstetrics, Jinan Maternity and Child Care Hospital, Jinan 250001, P.R. China.



Our work aimed to identify pathway-related modules and hub genes involved in invasive squamous cervical cancer (SCC) based on topological centralities analysis of networks.

Materials and Methods:

To determine the functional modules changed in SCC, functional enrichment analyses were performed for differentially expressed genes (DEGs) between invasive SCC samples and normal controls. Then, co-expression network was constructed using EBcoexpress approach based on the DEGs. Moreover, pathway-related modules were probed from the global co-expression network based on pathway genes and their adjacent genes. Finally, topological centralities for co-expression network and pathway-related subnetworks were carried out to explore hub genes and significant pathway-related functional modules.


Functional analyses revealed that DEGs mainly involved in three biological processes (metabolic process, cellular process, and cellular component organization) and 8 significant pathways. Furthermore, the co-expression network with 659 nodes and 1087 edges and 8 pathway-related modules were obtained. Topological centralities indicated two significant modules (cell cycle and base excision repair pathway-related modules), in which the common hub gene ARFGAP3 showed the most significant importance.


The bioinformatics elucidation of certain pathway-related modules and hub genes might be beneficial to understand the molecular pathogenesis and reveal their potential as novel molecular markers of SCC to a great extent.


Hub gene; module; pathway; squamous cervical cancer; topological centrality

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