Monoclonal B-cell lymphocytosis with renal involvement

Saudi J Kidney Dis Transpl. 2018 Nov-Dec;29(6):1502-1505. doi: 10.4103/1319-2442.248281.

Abstract

We report the case of a 70-year-old man with no relevant past medical history who presented with acute kidney injury. Kidney biopsy showed diffuse interstitial infiltration with typical chronic lymphocytic leukemia (CLL) phenotype B-cells. Subsequent studies revealed a normal lymphocyte count in the peripheral blood, and there was no evidence of lymphadenopathy or hepatosplenomegaly. Blood flow cytometry demonstrated a clonal B-cell population with a CLL phenotype. Without renal involvement, this case should be classified as monoclonal B-cell lymphocytosis. Renal function improved with steroid therapy. However, the patient developed CLL with significant lymphocytosis approximately two years later.

Publication types

  • Case Reports

MeSH terms

  • Acute Kidney Injury / drug therapy
  • Acute Kidney Injury / immunology*
  • Acute Kidney Injury / pathology
  • Aged
  • B-Lymphocytes / drug effects
  • B-Lymphocytes / immunology*
  • B-Lymphocytes / pathology
  • Biopsy
  • Disease Progression
  • Fatal Outcome
  • Glucocorticoids / therapeutic use
  • Humans
  • Kidney / drug effects
  • Kidney / immunology*
  • Kidney / pathology
  • Leukemia, Lymphocytic, Chronic, B-Cell / immunology*
  • Leukemia, Lymphocytic, Chronic, B-Cell / pathology
  • Lymphocytosis / drug therapy
  • Lymphocytosis / immunology*
  • Lymphocytosis / pathology
  • Male
  • Phenotype
  • Treatment Outcome

Substances

  • Glucocorticoids