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Curr Drug Deliv. 2019;16(5):386-399. doi: 10.2174/1567201816666181227112421.

Novel Drug Targets with Traditional Herbal Medicines for Overcoming Endometriosis.

Author information

1
Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Etiler 06330, Ankara, Turkey.
2
Department of Pharmacognosy, Faculty of Pharmacy, Van Yuzuncu Yil University, Tusba 65080, Van, Turkey.

Abstract

Endometriosis is a disease in which the lining of the endometrium is found outside of the uterus. Recent medical treatments for endometriosis have adverse effects, limiting their long-term use. Furthermore, the recurrence of the disease after the cessation of therapy is quite common, and most patients need to continue treatment to maintain a hypoestrogenic environment till conception. Notwithstanding recent advances in computational and chemical practices, traditional medicines are considered the most consistent sources for the discovery of new drugs. Numerous medicinal plants and plantderived compounds have been tested against gynecological disorders, mainly endometriosis. This review aimed to describe the pharmacological activity profile of the medicinal plants and their active ingredients and draw attention to the discovery of multitargeted drug molecules for rational therapy.

KEYWORDS:

Endometriosis; cervix; endometrium; glandular-cystic hyperplasia; phytochemicals; plants.

PMID:
30588884
PMCID:
PMC6637095
DOI:
10.2174/1567201816666181227112421
[Indexed for MEDLINE]
Free PMC Article

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