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Fetal Pediatr Pathol. 2018 Dec 27:1-9. doi: 10.1080/15513815.2018.1547338. [Epub ahead of print]

Rotavirus Infection Enhances Levels of Autoantibodies Against Islet Cell Antigens GAD65 and IA-2 in Children with Type 1 Diabetes.

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a Department of Virology , Faculty of Medicine, Iran University of Medical Sciences , Tehran , The Islamic Republic of Iran.



Some studies implicate rotavirus infection as a trigger for the development of type 1 diabetes mellitus (T1DM) in children, however findings are controversial.


We investigated the link between rotavirus infection and autoantibodies against islet antigens and T1DM in children.


Serum samples from 80 new-onset diabetic and 80 nondiabetic children were screened for anti-rotavirus IgG, anti-GAD65 and anti-IA-2 autoantibodies using ELISA kits.


Positivity percentages of anti-rotavirus IgG detection in diabetic and nondiabetic children were 51.3% and 35.0%, respectively (p = 0.03). The mean anti-GAD65 and anti-IA-2 antibody titers in anti-rotavirus IgG positive samples were statistically higher than that the anti-rotavirus IgG negative samples. A positive correlation was found between anti-rotavirus IgG and anti-GAD65 antibody levels (p = 0.004; r = 0.22).


Our findings support the hypothesis that rotovirus infection may induce T1DM in children.


T1DM; autoantibodies; children; rotavirus; type 1 diabetes

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