Format

Send to

Choose Destination
In Vivo. 2019 Jan-Feb;33(1):53-55. doi: 10.21873/invivo.11438.

Effects of Medium Molecular Weight Heparinyl Phenylalanine on Type I Hypersensitivity.

Author information

1
Research and Development Center, Fuso Pharmaceutical Industries Ltd, Osaka, Japan sei-takeda@fuso-pharm.co.jp.
2
Research and Development Center, Fuso Pharmaceutical Industries Ltd, Osaka, Japan.
3
Department of Pharmacology I, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, Japan.

Abstract

BACKGROUND/AIM:

We investigated the inhibitory action of medium molecular weight heparinyl phenylalanine (MHF) on type I hypersensitivity in comparison with medium molecular weight heparinyl arginine (MHR).

MATERIALS AND METHODS:

MHF and MHR were synthesized from heparin (HE) to decrease the side-effect of HE based on its anticoagulant action and used in this study.

RESULTS:

MHF demonstrated a significant inhibitory action on 48-h homologous passive cutaneous anaphylaxis in rats. Although MHF did not affect the death of mice injected with a lethal dose of histamine, it significantly prolonged the survival time of mice administered a lethal dose of compound 48/80. On the other hand, MHR did not inhibit type I hypersensitivity.

CONCLUSION:

The inhibitory action of MHF on the type I allergic reaction was due to a reduction or delay in histamine release from mast cells. MHF may be a potent anti-allergic agent.

KEYWORDS:

Medium molecular weight heparinyl arginine (MHR); Medium molecular weight heparinyl phenylalanine (MHF); Type I hypersensitivity

PMID:
30587602
DOI:
10.21873/invivo.11438

Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center