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J Asian Nat Prod Res. 2018 Dec 26:1-10. doi: 10.1080/10286020.2018.1520222. [Epub ahead of print]

Bioactive naphthoquinone and anthrone derivatives from endophytic Micromonospora sp. NEAU-gq13.

Author information

1
a Zhejiang Key Laboratory of Antifungal Drugs , Zhejiang Hisun Pharmaceutical Co., Ltd , Taizhou 318000 , China.
2
b Life Science and Biotechnology Research Center, School of Life Science , Northeast Agricultural University , Harbin 150030, China.

Abstract

Two new naphthalenone derivatives, 5-hydroxy-4-oxo-2-(2-oxopropyl)-1,2,3,4-tetrahydronaphthalen-1-yl acetate (1) and 5-hydroxy-2-(2-hydroxypropyl)naphthalene-1,4-dione (2), together with two new anthrone derivatives, (S)-2,5-dihydroxy-2-methyl-1,2,3,4-tetrahydroanthracene-9,10-dione (3) and 4,5-dihydroxy-2-methyl-9H-xanthen-9-one (4), were isolated from the fermentation broth of endophytic Micromonospora sp. NEAU-gq13. Their structures were determined by 1D-NMR, 2D-NMR, and HR-ESI-MS analysis. Compounds 2 and 3 exhibited strong cytotoxic activity against human central nervous system cancer (SF-268) with the IC50 values of 3.04 and 5.66 μg/ml, respectively. Moreover, compound 2 also displayed potent activity against human liver cancer (HepG2) with an IC50 value of 1.01 μg/ml.

KEYWORDS:

Endophytic micro-organisms; Micromonospora sp. NEAU-gq13; cytotoxic activities; naphthoquinone and anthrone derivatives

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