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J Parkinsons Dis. 2018;8(s1):S47-S51. doi: 10.3233/JPD-181482.

The Future of Brain Imaging in Parkinson's Disease.

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Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Donders Centre for Cognitive Neuroimaging, Nijmegen, The Netherlands.
University of Florida, Applied Physiology and Kinesiology, Neurology, and Biomedical Engineering, Gainesville, FL, USA.
Department of Nuclear Medicine and PET Centre, Aarhus University Hospital, Aarhus, Denmark, Division of Neuroscience, Newcastle University, Newcastle, UK.


Parkinson's disease (PD) is a progressive neurodegenerative disorder that is associated with distinct abnormalities in brain function and structure. Here we discuss how future developments in functional, structural and nuclear brain imaging may help us to better understand, diagnose, and potentially even treat PD. These new horizons may be reached by developing tracers that specifically bind to alpha synuclein, by looking into different places in the body (such as the gut) or in smaller cerebral nuclei (with improved spatial resolution), and by developing new approaches for quantifying and interpreting altered dynamics in large-scale brain networks.


Parkinson’s disease; biomarkers; magnetic resonance imaging; neuroimaging; positron emission tomography

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