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Alzheimers Dement (N Y). 2018 Dec 14;4:737-745. doi: 10.1016/j.trci.2018.10.010. eCollection 2018.

The SCD-Well randomized controlled trial: Effects of a mindfulness-based intervention versus health education on mental health in patients with subjective cognitive decline (SCD).

Author information

1
Division of Psychiatry, University College London, London, United Kingdom.
2
Mood Disorders Centre, University of Exeter, Exeter, United Kingdom.
3
Swiss Center for Affective Sciences, Department of Medicine and Department of Psychology, University of Geneva, Geneva, Switzerland.
4
Inserm, Inserm UMR-S U1237, Université de Caen-Normandie, GIP Cyceron, Caen, France.
5
Lyon Neuroscience Research Center Inserm U1028, CNRS UMR5292, Lyon, France.
6
GIGA-CRC In Vivo Imaging, Université de Liège, Liège, Belgium.
7
Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humbold-Universität zu Berlin and Berlin Institute of Health, NeuroCure Clinical Research Center, Berlin, Germany.
8
Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humbold-Universität zu Berlin and Berlin Institute of Health, Centre for Stroke Research Berlin, Berlin, Germany.
9
Department of Psychiatry, Medical Faculty, University of Cologne, Cologne, Germany.
10
Alzheimer's Disease and Other Cognitive Disorders Unit, Hospital Clinic, IDIBAPS, Barcelona, Spain.
11
Hospices Civils de Lyon, Institut du Vielllissement, CRC Vielllissement-Cerveau-Fragilité, Lyon, France.
12
Lyon Institute for Elderly, Clinical and Research Memory Centre of Lyon, Hospices Civils de Lyon, Inserm 1048, CNRS 5292, Lyon 1 University, Lyon, France.
13
Essex Partnership University NHS Foundation Trust.
14
EUCLID/F-CRIN Clinical Trials Platform, University of Bordeaux, Inserm, Bordeaux Population Health Center, Bordeaux, France.
15
CHU Bordeaux, Service d'information médicale, Bordeaux, France.
16
German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.

Abstract

Introduction:

Subjectively experienced cognitive decline in older adults is an indicator of increased risk for dementia and is also associated with increased levels of anxiety symptoms. As anxiety is itself emerging as a risk factor for cognitive decline and dementia, the primary question of the present study is whether an 8-week mindfulness-based intervention can significantly reduce anxiety symptoms in patients with subjective cognitive decline (SCD). The secondary questions pertain to whether such changes extend to other domains of psychological, social, and biological functioning (including cognition, self-regulation, lifestyle, well-being and quality of life, sleep, and selected blood-based biomarkers) associated with mental health, older age, and risk for dementia.

Methods:

SCD-Well is a multicenter, observer-blinded, randomized, controlled, superiority trial, which is part of the Horizon 2020 European Union-funded "Medit-Ageing" project. SCD-Well compares an 8-week mindfulness- and compassion-based intervention specifically adapted for older adults with SCD with a validated 8-week health education program. Participants were recruited from memory clinics in four European sites (Cologne, Germany; London, United Kingdom; Barcelona, Spain; and Lyon, France) and randomized with a 1:1 allocation, stratified by site.

Results:

The primary outcome, change in anxiety symptoms, and secondary outcomes reflecting psychological, cognitive, social, and biological functioning are assessed at baseline, postintervention, and 4 months after the end of the intervention.

Discussion:

The study will provide evidence on whether a mindfulness-based intervention can effect changes in anxiety and other risk factors for cognitive decline and dementia in older adults with SCD and will inform the establishment of intervention strategies targeted at improving mental health in older adults.

KEYWORDS:

Alzheimer's disease; Anxiety; Cognition; Compassion; Dementia; Emotion; Medit-Ageing; Meditation; Mindfulness; Psychoeducation; Silver Santé Study; Subjective cognitive decline

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