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Alzheimers Dement (N Y). 2018 Dec 14;4:714-723. doi: 10.1016/j.trci.2018.10.011. eCollection 2018.

The Age-Well randomized controlled trial of the Medit-Ageing European project: Effect of meditation or foreign language training on brain and mental health in older adults.

Author information

1
Université Normandie, Inserm, Université de Caen-Normandie, Inserm UMR-S U1237, GIP Cyceron, Caen, France.
2
GIGA-CRC, In Vivo Imaging, Université de Liège, Liège, Belgium.
3
Belgian National Fund for Scientific Research (F.R.S.-FNRS), Brussels, Belgium.
4
Swiss Center for Affective Sciences, Department of Medicine and Department of Psychology, University of Geneva, Geneva, Switzerland.
5
Division of Psychiatry, University College London, London, United Kingdom.
6
Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humbold-Universität zu Berlin and Berlin Institute of Health, NeuroCure Clinical Research Center, Berlin, Germany.
7
Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humbold-Universität zu Berlin and Berlin Institute of Health, Centre for Stroke Research Berlin, Berlin, Germany.
8
Université Normandie, Inserm, Université de Caen-Normandie, Inserm UMR-S U1077, GIP Cyceron, Caen, France.
9
CHU Caen-Normandie, Department of Clinical Research, Caen, France.
10
Department of Medicine, University of Geneva, Geneva, Switzerland.
11
EUCLID/F-CRIN Clinical Trials Platform, University of Bordeaux, INSERM, Bordeaux Population Health Center, Bordeaux, France.
12
CHU Bordeaux, F-33000, Bordeaux, France.
13
Lyon Neuroscience Research Center INSERM U1028, CNRS UMR5292, Lyon University, Lyon, France.

Abstract

Introduction:

The Age-Well clinical trial is an ongoing monocentric, randomized, controlled trial aiming to assess an 18-month preventive meditation-based intervention directly targeting the attentional and emotional dimensions of aging to promote mental health and well-being in elderly people.

Methods:

One hundred thirty-seven cognitively unimpaired older adults are randomized to either an 18-month meditation-based intervention, a structurally matched foreign language training, or a passive control arm. The impact of the intervention and underlying mechanisms are assessed with detailed cognitive, behavioral, biological, neuroimaging and sleep examinations.

Results:

Recruitment began in late 2016 and ended in May 2018. The interventions are ongoing and will be completed by early 2020.

Discussion:

This is the first trial addressing the emotional and cognitive dimension of aging with a long-term nonpharmacological approach and using comprehensive assessments to investigate the mechanisms. Results are expected to foster the development of preventive strategies reducing the negative impact of mental conditions and disorders.

KEYWORDS:

Aging; Alzheimer's disease; Attention; Blood markers; Cognition; Compassion; Dementia; Emotion; Foreign language training; Lifestyle; Meditation; Mindfulness; Neuroimaging; Prevention; Reserve; Sleep

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