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Data Brief. 2018 Dec 6;22:140-144. doi: 10.1016/j.dib.2018.12.007. eCollection 2019 Feb.

Transmission Electron Microscopy Data on drusen-like deposits in the retinal degeneration sTg-IRBP: HEL mouse model.

Author information

1
Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.
2
Microscopy and Histology Core Facility, University of Aberdeen, Aberdeen, UK.
3
Department of Ophthalmology, NHS Grampian, Aberdeen, UK.
4
University of Western Australia, Lions Eye Institute, Perth, Australia.

Abstract

Histology (H&E) and transmission electron microscopy (TEM) data are provided showing age-related changes in the retinal structure of sTg-IRBP:HEL mice. These include substantial photoreceptor loss, atrophy of the retinal pigment epithelium, Bruch׳s membrane disruption and thickening, along with the presence of drusenoid deposits and changes in basal laminar infoldings. These features resemble some of those key characteristics found in the course of human dry (atrophic) age-related macular degeneration (AMD), particularly with regard to drusen. Hence, we believe the sTg-IRBP:HEL mouse model represents a useful and promising archetype for future study of the mechanism of drusen formation in AMD.

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