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Open Forum Infect Dis. 2018 Nov 16;5(12):ofy301. doi: 10.1093/ofid/ofy301. eCollection 2018 Dec.

Plasma Cell-Free DNA Next-Generation Sequencing to Diagnose and Monitor Infections in Allogeneic Hematopoietic Stem Cell Transplant Patients.

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Division of Infectious Diseases, University of California San Francisco, San Francisco, California.
Karius, Inc., Redwood City, California.
School of Medicine, University of California Davis, Sacramento, California.
Division of Hematology and Blood and Marrow Transplantation, University of California San Francisco, San Francisco, California.


Allogeneic hematopoietic stem cell transplant patients are at risk for common and atypical infections. Superior diagnostics can decrease infection-related morbidity and mortality. A novel plasma cell-free DNA next-generation sequencing test detected an uncommon presentation of Chlamydia trachomatis and recurrent and metastatic complications of Staphylococcus aureus bacteremia before standard microbiology.


immunocompromised; molecular diagnostics; next-generation sequencing; stem cell transplant

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