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J Med Virol. 2018 Dec 22. doi: 10.1002/jmv.25386. [Epub ahead of print]

Cytomegalovirus shedding from breastmilk and mucosal sites in healthy postpartum women: A pilot study.

Author information

1
University of California, Davis, UC Davis School of Medicine, Davis, CA.
2
Providence Health and Services, Seattle, WA.
3
Departments of Medicine and Laboratory Medicine, University of Washington, Seattle, WA.
4
Fred Hutchinson Cancer Research Center, Vaccine and Infectious Diseases Division, Seattle, WA.

Abstract

Mother-to-child cytomegalovirus (CMV) breastmilk transmission can occur in the postnatal period. In a pilot study, we measured daily CMV detection by polymerase chain reaction in breastmilk, vaginal, and saliva samples from nine healthy CMV-seropositive postpartum women for 28 days. CMV was found in seven of nine women and 171 of 253 breastmilk samples (67.6%). In four women, all breastmilk samples were positive. CMV was less frequently detected in the vagina (39 of 258, 15.1%) and saliva (53 of 258, 20.5%). Daily breastmilk, oral, and genital collection is feasible and demonstrates high variability between women. Further study of the dynamics of CMV in distinct anatomic compartments is warranted.

KEYWORDS:

breastmilk; cytomegalovirus; postpartum

PMID:
30578684
DOI:
10.1002/jmv.25386

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