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BMC Microbiol. 2018 Dec 22;18(1):221. doi: 10.1186/s12866-018-1369-3.

Characterization of a Lactobacillus brevis strain with potential oral probiotic properties.

Fang F1,2, Xu J3,4, Li Q3,4, Xia X3,4, Du G3,5.

Author information

1
Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, 214122, China. ffang@jiangnan.edu.cn.
2
State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, 214122, China. ffang@jiangnan.edu.cn.
3
Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, 214122, China.
4
State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, 214122, China.
5
The Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, Wuxi, 214122, China.

Abstract

BACKGROUND:

The microflora composition of the oral cavity affects oral health. Some strains of commensal bacteria confer probiotic benefits to the host. Lactobacillus is one of the main probiotic genera that has been used to treat oral infections. The objective of this study was to select lactobacilli with a spectrum of probiotic properties and investigate their potential roles in oral health.

RESULTS:

An oral isolate characterized as Lactobacillus brevis BBE-Y52 exhibited antimicrobial activities against Streptococcus mutans, a bacterial species that causes dental caries and tooth decay, and secreted antimicrobial compounds such as hydrogen peroxide and lactic acid. Compared to other bacteria, L. brevis BBE-Y52 was a weak acid producer. Further studies showed that this strain had the capacity to adhere to oral epithelial cells. Co-incubation of L. brevis BBE-Y52 with S. mutans ATCC 25175 increased the IL-10-to-IL-12p70 ratio in peripheral blood mononuclear cells, which indicated that L. brevis BBE-Y52 could alleviate inflammation and might confer benefits to host health by modulating the immune system.

CONCLUSIONS:

L. brevis BBE-Y52 exhibited a spectrum of probiotic properties, which may facilitate its applications in oral care products.

KEYWORDS:

Adhesion; Antimicrobial activity; Hydrogen peroxide; Immunomodulation; Lactobacillus brevis

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