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Int J Mol Sci. 2018 Dec 20;20(1). pii: E6. doi: 10.3390/ijms20010006.

Standardized Aronia melanocarpa Extract as Novel Supplement against Metabolic Syndrome: A Rat Model.

Author information

1
Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia. drvladakgbg@yahoo.com.
2
Department of Human Pathology, 1st Moscow State Medical, University IM Sechenov, Trubetskaya street 8, Moscow 119991, Russia. drvladakgbg@yahoo.com.
3
Department of Pharmacy, High Medical School of Professional Studies in Cuprija, Lole Ribara 1/2, 35000 Cuprija, Serbia. milic.milic@gmail.com.
4
Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia. jovanabradickg@gmail.com.
5
Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia. jovana.jeremic@medf.kg.ac.rs.
6
Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia. vladimirziv@gmail.com.
7
Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia. ivan_srejovic@hotmail.com.
8
Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia. tamara.nikolic@medf.kg.ac.rs.
9
Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia. isidora.stojic@medf.kg.ac.rs.
10
Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia. nbarudzic@hotmail.com.
11
Department of Human Pathology, 1st Moscow State Medical, University IM Sechenov, Trubetskaya street 8, Moscow 119991, Russia. bolevich2011@yandex.ru.
12
Institute of Histology and Embryology "Aleksandar Dj. Kostic", Faculty of Medicine, University of Belgrade, Dr Subotic 8, 11000 Belgrad, Serbia. milica.borovic@supremalab.rs.
13
Pharmanova, Generala Anrija 6, 11010 Belgrade, Serbia. miroslav.mitrovic@pharmanova.com.
14
Institute for Medical Research, Centre of Research Excellence in Nutrition and Metabolism, University of Belgrade, Tadeusa Koscuska 1, 11129 Belgrade, Serbia. vesna.vucic.imr@gmail.com.

Abstract

The aim of our study was to examine the effects of different dietary strategies, high-fat (HFd) or standard diet (Sd) alone or in combination with standardized oral supplementation (0.45 mL/kg/day) of Aronia melanocarpa extract (SAE) in rats with metabolic syndrome (MetS). SAE is an official product of pharmaceutical company Pharmanova (Belgrade, Serbia); however, the procedure for extraction was done by EU-Chem company (Belgrade, Serbia). Rats were divided randomly into six groups: control with Sd, control with Sd and SAE, MetS with HFd, MetS with HFd and SAE, MetS with Sd and MetS with Sd and SAE during 4 weeks. At the end of the 4-week protocol, cardiac function and liver morphology were assessed, while in the blood samples glucose, insulin, iron levels and systemic redox state were determined. Our results demonstrated that SAE had the ability to lower blood pressure and exert benefits on in vivo and ex vivo heart function. Moreover, SAE improved glucose tolerance, attenuated pathological liver alterations and oxidative stress present in MetS. Obtained beneficial effects of SAE were more prominent in combination with changing dietary habits. Promising potential of SAE supplementation alone or in combination with different dietary protocols in triggering cardioprotection should be further examined in future.

KEYWORDS:

Aronia melanocarpa; dietary strategies; metabolic syndrome; standardized extract; supplementation

PMID:
30577476
PMCID:
PMC6337203
DOI:
10.3390/ijms20010006
[Indexed for MEDLINE]
Free PMC Article

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