Format

Send to

Choose Destination
J Perinatol. 2019 Feb;39(2):286-294. doi: 10.1038/s41372-018-0299-0. Epub 2018 Dec 20.

Risk of preterm and early term birth by maternal drug use.

Author information

1
Department of Pediatrics, University of California San Diego, La Jolla, CA, USA. rjbaer@ucsd.edu.
2
California Preterm Birth Initiative, University of California San Francisco, San Francisco, CA, USA. rjbaer@ucsd.edu.
3
Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.
4
Departments of Epidemiology and Pediatrics, University of Iowa, Iowa City, IA, USA.
5
California Preterm Birth Initiative, University of California San Francisco, San Francisco, CA, USA.
6
Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.
7
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, San Francisco, CA, USA.

Abstract

OBJECTIVE:

Examine the risk of preterm birth (PTB, < 37 weeks) and early term birth (37-38 weeks) for women with reported drug abuse/dependence.

STUDY DESIGN:

The population was drawn from singleton livebirths in California from 2007 to 2012. Drug abuse/dependence was determined from maternal diagnostic codes (opioid, cocaine, cannabis, amphetamine, other, or polysubstance). Relative risks, adjusted for maternal factors were calculated for PTB and early term birth.

RESULT:

Of the 2,890,555 women in the sample, 1.7% (n = 48,133) had a diagnostic code for drug abuse/dependence. The percentage of PTBs varied from 11.6% (cannabis) to 24.3% (cocaine), compared with 6.7% of women without reported drug abuse/dependence.

CONCLUSION:

Women with reported drug abuse/dependence during pregnancy were at increased risk of having a PTB and all but those using cannabis were at risk of having an early term birth. Women using cocaine and polysubstance were at the highest risk of birth < 32 weeks.

PMID:
30573752
DOI:
10.1038/s41372-018-0299-0

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center