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Semin Radiat Oncol. 2019 Jan;29(1):6-15. doi: 10.1016/j.semradonc.2018.10.009.

Targeting NAD+ Metabolism to Enhance Radiation Therapy Responses.

Author information

1
The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA. Electronic address: joshlewis@gatech.edu.
2
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN.
3
Department of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, NC.
4
Departments of Surgery, UT Southwestern Medical Center, Dallas, TX.
5
Departments of Biochemistry, UT Southwestern Medical Center, Dallas, TX.
6
The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA.

Abstract

Nicotinamide adenine dinucleotide (NAD+) metabolism is integrally connected with the mechanisms of action of radiation therapy and is altered in many radiation-resistant tumors. This makes NAD+ metabolism an ideal target for therapies that increase radiation sensitivity and improve patient outcomes. This review provides an overview of NAD+ metabolism in the context of the cellular response to ionizing radiation, as well as current therapies that target NAD+ metabolism to enhance radiation therapy responses. Additionally, we summarize state-of-the-art methods for measuring, modeling, and manipulating NAD+ metabolism, which are being used to identify novel targets in the NAD+ metabolic network for therapeutic interventions in combination with radiation therapy.

PMID:
30573185
PMCID:
PMC6310039
[Available on 2020-01-01]
DOI:
10.1016/j.semradonc.2018.10.009
[Indexed for MEDLINE]

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