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Vasc Endovascular Surg. 2019 Apr;53(3):230-241. doi: 10.1177/1538574418814612. Epub 2018 Dec 20.

A Systematic Review of the Use of Biochemical Markers in the Assessment of Spinal Cord Ischemia in Thoracoabdominal Aortic Aneurysm Repair.

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1 SingVaSC, Singapore Vascular Surgical Collaborative, Singapore.
2 Cardiovascular Research Institute, National University of Singapore, Singapore.
3 Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
4 Division of Vascular Surgery, National University Heart Centre, Singapore.
5 Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
6 Department of Genome Biology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
7 Department of Anaesthetics and Intensive Care, North Middlesex University Hospital, London, United Kingdom.
8 Department of Anaesthetics, London North West Healthcare NHS Trust, Middlesex, United Kingdom.
9 Imperial Vascular Unit, St Mary's Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom.



Despite advances in perioperative critical care and surgical technique, spinal cord ischemia remains a devastating complication of thoracic and thoracoabdominal aortic aneurysm repair. Biochemical markers present in peripheral blood and cerebrospinal fluid (CSF) may be useful in assessing spinal cord injury. We systematically analyze and report the role of all reported biochemical markers that have been used in assessing and diagnosing spinal cord ischemia in thoracic and thoracoabdominal aortic aneurysm repair.


Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines were used for this review. Published literature was searched to identify all studies reporting on the use of biochemical markers in thoracoabdominal aortic aneurysm repair in the assessment of spinal cord ischemia. Marker-specific and patient-specific data were extracted from all studies and where possible, subgroup analysis was performed on marker-specific data sets.


Fourteen studies of 321 patients undergoing thoracic and thoracoabdominal aortic aneurysm repair were eligible for further analysis. Seven distinct biochemical markers were used in both CSF and blood samples: S100B proteins (S100B), neurone-specific enolase, lactate dehydrogenase, glial fibrillary acidic protein (GFAp), neurofilament triplet protein (NFL) and Tau protein, and glucose. There was substantial evidence demonstrating the heightened levels of S100, NFL, and GFAp in CSF in patients with spinal cord ischemia. There is however, wide variability in the correlation of the same 6 biochemical markers in peripheral blood and spinal cord ischemia.


In patients with spinal cord injury, dramatic rises occur with S100B, NFL, and GFAp in CSF. However, further work is needed if biochemical markers are to impact on the future of thoracoabdominal aortic aneurysm repair.


GFAp; S100; biochemical markers; spinal cord ischemia; thoracoabdominal aortic aneurysm repair

[Indexed for MEDLINE]

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