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Biomed Pharmacother. 2019 Feb;110:930-942. doi: 10.1016/j.biopha.2018.12.001. Epub 2018 Dec 17.

Differential modulation of immune response and cytokine profiles of Sargassum horneri ethanol extract in murine spleen with or without Concanavalin A stimulation.

Author information

1
Interdisciplinary Graduate Program in Advanced Convergence Technology & Science, Jeju National University, Jeju 63243, Republic of Korea.
2
Department of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University, Jeju 63243, Republic of Korea.
3
Department of Marine Life Science, School of Marine Biomedical Sciences, Jeju National University, Jeju 690-756, Republic of Korea.
4
Department of Food Technology and Nutrition, Chonnam National University, Yeosu 59626, Republic of Korea.
5
Seojin Biotech Co.Ltd, Acedongbaek Tower, 1-501∼504, 16-4, Dongbaekjungang-ro, 16 beon-gil, Gieung-gu, Yongin-si, Gyeonggi-do, 17015, Republic of Korea.
6
Department of Biology and Research Institute for Basic Sciences, Jeju National University, Jeju 63243, Republic of Korea.
7
Department of Food Technology and Nutrition, Chonnam National University, Yeosu 59626, Republic of Korea; Department of Marine Bio Food Science, Chonnam National University, Yeosu 59626, Republic of Korea.
8
Interdisciplinary Graduate Program in Advanced Convergence Technology & Science, Jeju National University, Jeju 63243, Republic of Korea; Department of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University, Jeju 63243, Republic of Korea. Electronic address: yhjee@jejunu.ac.kr.

Abstract

The health benefit of brown seaweeds has been proclaimed for centuries, particularly in Asian countries. A brown seaweed Sargassum horneri has been suggested to have immune-boosting and anti-inflammatory/immune-regulatory effects, but their mechanism is still elusive. This study researches the immunological effect of 70% ethanol extract of S. horneri (SHE) on unstimulated and Con A-stimulated murine splenocytes. When treated alone, SHE had an immune stimulatory effect on CD3e+ CD4+ T-helper cells, CD3e+ CD8+ cytotoxic T cells, CD45+ CD11b+ macrophages, Ly-6C+ Ly-6 G+ granulocytes, and Ly6 G- Ly6Clow eosinophils. Furthermore, SHE enhanced wide spectrum of Th cytokines such as TNF-α, IFN-γ (Th1), IL-4, IL-5, IL-13 (Th2), and IL-6 (Th17), which also stimulated the macrophage polarizing cytokines and enhanced macrophage derived cytokine secretion. SHE in Con A (5 μg/mL) stimulated cells decreased T-helper, cytotoxic T cells, granulocytes, eosinophils, and monocytes. These results signify the potential immuno-modulatory effect of SHE which can be developed as a therapeutic agent in immuno-compromised individuals.

KEYWORDS:

Anti-inflammation; Con A; Immunostimulation; Th cytokines

PMID:
30572197
DOI:
10.1016/j.biopha.2018.12.001
[Indexed for MEDLINE]
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