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Alcohol Clin Exp Res. 2019 Feb;43(2):277-286. doi: 10.1111/acer.13929. Epub 2018 Dec 20.

Reduced Risk of Alcohol-Induced Pancreatitis With Cannabis Use.

Author information

1
Department of Medicine , North Shore Medical Center, Salem, Massachusetts.
2
Department of Medicine , University of Massachusetts Medical School, Worcester, Massachusetts.
3
School of Public Health , University of Massachusetts Lowell, Lowell, Massachusetts.
4
Division of Hospital Medicine , University of Kentucky College of Medicine, Lexington, Kentucky.
5
INRS-Institut Armand-Frappier , Institut National de la Recherche Scientifique, Laval, Québec, Canada.

Abstract

BACKGROUND:

Pancreatitis is an increasingly common clinical condition that causes significant morbidity and mortality. Cannabis use causes conflicting effects on pancreatitis development. We conducted a larger and more detailed assessment of the impact of cannabis use on pancreatitis.

METHODS:

We analyzed data from 2012 to 2014 of the Healthcare Cost and Utilization Project-Nationwide Inpatient Sample discharge records of patients 18 years and older. We used the International Classification of Disease, Ninth Edition codes, to identify 3 populations: those with gallstones (379,125); abusive alcohol drinkers (762,356); and non-alcohol-non-gallstones users (15,255,464). Each study population was matched for cannabis use record by age, race, and gender, to records without cannabis use. The estimation of the adjusted odds ratio (aOR) of having acute and chronic pancreatitis (AP and CP) made use of conditional logistic models.

RESULTS:

Concomitant cannabis and abusive alcohol use were associated with reduced incidence of AP and CP (aOR: 0.50 [0.48 to 0.53] and 0.77 [0.71 to 0.84]). Strikingly, for individuals with gallstones, additional cannabis use did not impact the incidence of AP or CP. Among non-alcohol-non-gallstones users, cannabis use was associated with increased incidence of CP, but not AP (1.28 [1.14 to 1.44] and 0.93 [0.86 to 1.01]).

CONCLUSIONS:

Our findings suggest a reduced incidence of only alcohol-associated pancreatitis with cannabis use.

KEYWORDS:

Alcohol Abuse; Cannabis; Gallstones; Incidence; Pancreatitis

PMID:
30570765
DOI:
10.1111/acer.13929

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