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Obesity (Silver Spring). 2019 Jan;27(1):145-151. doi: 10.1002/oby.22332.

Examining Endocrine Disruptors Measured in Newborn Dried Blood Spots and Early Childhood Growth in a Prospective Cohort.

Author information

1
Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA.
2
Department of Environmental Health Sciences, University at Albany School of Public Health, Albany, New York, USA.
3
Department of Epidemiology and Biostatistics, University at Albany School of Public Health, Albany, New York, USA.
4
Biostatistics and Bioinformatics Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA.
5
Department of Pediatrics, New York University School of Medicine, New York, New York, USA.
6
Department of Environmental Medicine, New York University School of Medicine, New York, New York, USA.
7
Department of Population Health, New York University School of Medicine, New York, New York, USA.
8
International Joint Research Center for Persistent Toxic Substances, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin, China.
9
New York State Department of Health, Wadsworth Center, Albany, New York, USA.
10
Dean's Office, College of Health and Human Services, George Mason University, Fairfax, Virginia, USA.

Abstract

OBJECTIVE:

The goal of this study was to determine whether newborn concentrations of perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), and bisphenol A (BPA) are associated with early childhood growth.

METHODS:

A total of 1,954 singletons and 966 twins from the Upstate KIDS Study (born 2008-2010) were included in this study. Newborn dried blood spot concentrations of PFOS, PFOA, and BPA were quantified by liquid chromatography tandem mass spectrometry. Children's weight and height were reported from birth through 3 years of age. Repeated measures were modeled using generalized linear mixed models.

RESULTS:

PFOS and PFOA were associated with lower BMI (-0.078 kg/m2 [-0.12 to -0.038] and -0.076 kg/m2 [-0.17 to -0.051] per 1 standard deviation increase in log PFOS and PFOA, respectively) and not with early obesity among singletons. Inconsistent associations were observed for twins. BPA levels were higher among neonates with a neonatal intensive care unit stay (P < 0.001), making associations difficult to interpret.

CONCLUSIONS:

Perfluorinated alkyl substances did not exhibit obesogenic associations with early measures of childhood growth. Blood-based BPA measures are limited by the nonpersistent nature of the chemical, and unknown sources from hospital settings may present only transient exposures.

PMID:
30569634
PMCID:
PMC6309795
[Available on 2020-01-01]
DOI:
10.1002/oby.22332

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