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Open Forum Infect Dis. 2018 Sep 15;5(10):ofy233. doi: 10.1093/ofid/ofy233. eCollection 2018 Oct.

Validation of an Antimicrobial Stewardship-Driven Verigene Blood-Culture Gram-Negative Treatment Algorithm to Improve Appropriateness of Antibiotics.

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University of Maryland School of Pharmacy, Department of Pharmacy Practice and Science, Baltimore.
University of Maryland Medical System, Department of Medicine, Baltimore.
University of Maryland School of Medicine, Departments of Epidemiology and Public Health, Baltimore.
University of Maryland School of Medicine, Department of Pathology, Baltimore.


Rapid diagnostic testing (RDT) allows for early adjustment of antibiotic therapy. This study examined the potential impact of a stewardship-driven antibiotic treatment algorithm, incorporating RDT into the management of Gram-negative bacteremia. The proposed algorithm would have resulted in 88.4% of cases receiving appropriate antibiotic therapy versus 78.1% by standard of care (P = .014).


diagnostic stewardship; multiplex PCR; rapid diagnostic

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