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Curr Opin Chem Eng. 2018 Mar;19:77-85. doi: 10.1016/j.coche.2017.12.009. Epub 2018 Jan 11.

Engineering a new generation of carbohydrate-based vaccines.

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Robert Frederick Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY 14853 USA.
Comparative Biomedical Sciences, Cornell University, Ithaca, NY 14853 USA.
Department of Biomedical Engineering, Cornell University, Ithaca, NY 14853 USA.


Recent advances in chemical synthesis, conjugation chemistry, engineered biosynthesis, and formulation design have spawned a new generation of vaccines that incorporate carbohydrate antigens. By providing better immunity against a variety of pathogens or malignant cells and lowering the cost of production, these developments overcome many of the limitations associated with conventional vaccines involving polysaccharides. Moreover, the resulting vaccine candidates are shedding light on how the immune system responds to carbohydrates and providing mechanistic insight that can help guide future vaccine design. Here, we review recent engineering efforts to develop and manufacture carbohydrate-based vaccines that are efficacious, durable, and cost-effective.

Conflict of interest statement

Competing financial interests. M.P.D. has a financial interest in Glycobia, Incorporated and Versatope, Incorporated. M.P.D.’s interests are reviewed and managed by Cornell University in accordance with their conflict of interest policies.

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