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J Emerg Trauma Shock. 2018 Oct-Dec;11(4):271-275. doi: 10.4103/JETS.JETS_72_17.

The Eminence of Neutrophil-lymphocyte Count Ratio in Predicting Bacteremia for Community-acquired Infections at an Emergency Medicine Department in a Tertiary Care Setting.

Author information

1
Department of Emergency Medicine, Amrita Institute of Medical Sciences, Amrita University, AIMS, Kochi, Kerala, India.
2
Department of Pharmacy Practice, Amrita School of Pharmacy, Amrita University, AIMS, Kochi, Kerala, India.

Abstract

Introduction:

The changes in the white blood cells counts and other blood parameters are well-recognized feature in sepsis. A ratio between neutrophils and lymphocytes can be used as a screening marker in sepsis. Even though new markers such as Procalcitonin and adrenomedullin have been rolled out in the field, implementation of these markers has been hindered by cost, accessibility, and proper validation. We looked for the ability of simple neutrophil-lymphocyte count ratio (NLCR) when compared to the gold standard blood culture method in predicting bacteremia, on patients presented to emergency department (ED) with features of suspected community-acquired infections.

Materials and Methods:

A comparative study done on 258 adult patients, admitted with suspected features of community-acquired infections. The study group included all patients who had positive blood culture results on index presentation at ED. Patients with hematological, chronic liver and retroviral diseases, patients receiving chemotherapy, and steroid medications were excluded from the study. The study group was compared with gender- and age-matched control group who were also admitted with a suspicion of the same, but in whom the blood culture results were negative.

Results:

There was no statistically significant difference for predicting bacteremia by NLCR (>4.63) and culture positivity methods (P = 1.00). NLCR of > 4.63 predicts bacteremia with an accuracy of 84.9%.

Conclusion:

In our setting, NLCR performs equally well with culture positivity, in detecting severe infection at the early phase of disease. The NLCR may, therefore, be used as a suitable screening marker at ED for suspected community-acquired infections.

KEYWORDS:

C-reactive protein; Community-acquired bacteremia; neutrophil-lymphocyte count ratio; septic shock; severe sepsis

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